Hi everyone –
I’m trying to set up a 1H / 19F HOESY on our AVANCE III HD instrument.
In the past, I’ve been told it’s an extremely difficult experiment
to set up (though it’s never been clear to me why), and I was never able
to get enough signal to noise from it on our NEO system at a previous job to make
it a useful tool, even for overnight analysis.
Does anyone have experience setting them up on a Bruker instrument? What are the
common failure modes?
I’ve managed to get both the 1D and 2D sequences to run without errors
on my instrument, but right now I’m getting absolutely no signal to noise
except for residual T1 noise in the 2D version. It’s possible I just don’t
have enough patience (and need to throw several thousand scans at the problem or
increase the concentration of my sample), but I’m wondering if there’s something
else I’m overlooking.
Thank you in advance!
Beth Moscato
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Received on Mon Mar 03 2025 - 09:30:27 MST