Hi Beth,
I seem to recall you used to need isolation filters to separate 1H/19F
In the "old days" they were these big scuba tank filters like they use on
radio antennae that had tuned cavitys...
Dan Plant
> From: main_at_ammrl.groups.io On Behalf Of Beth Moscato= via groups.io
> Sent: Monday, March 3, 2025 11:36 AM
> To: main <main_at_ammrl.groups.io>
> Subject: [AMMRL] 1H-19F HOESY setup tips?
Hi everyone -
I'm trying to set up a 1H / 19F HOESY on our AVANCE III HD instrument. In the
past, I've been told it's an extremely difficult experiment to set up (though
it's never been clear to me why), and I was never able to get enough signal
to noise from it on our NEO system at a previous job to make it a useful
tool, even for overnight analysis.
Does anyone have experience setting them up on a Bruker instrument? What are
the common failure modes?
I've managed to get both the 1D and 2D sequences to run without errors on my
instrument, but right now I'm getting absolutely no signal to noise except
for residual T1 noise in the 2D version. It's possible I just don't have
enough patience (and need to throw several thousand scans at the problem or
increase the concentration of my sample), but I'm wondering if there's
something else I'm overlooking.
Thank you in advance!
Beth Moscato
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Received on Mon Mar 03 2025 - 09:35:20 MST