Hi Wendy,
yes, add the mixture to your solvent table. I think that is the best way.
The sulfuric acid is shifting the D2O signal significantly.
I cannot help you with the exact shift, maybe you measure it in advance
adding a trimethylsilyl propionic acid salt as standard.
And maybe your user should add the standard to if it not interfering with
their substances.
Good luck!
Erica
> Von: main_at_ammrl.groups.io Im Auftrag von Wendy Breyer via groups.io
> Gesendet: Montag, 12. Mai 2025 23:00
> An: main_at_ammrl.groups.io
> Betreff: [AMMRL] Adding 40/60 D2O/d-sulfuric acid as a lock solvent?
Hello,
A user ran a reaction in a ~40/60 D2O/d-sulfuric acid mixture so that she
could directly analyze her products via NMR. However, when she used D2O as
the lock solvent, she found her peaks shifted significantly (e.g. aromatic
peaks at 2-3ppm). We are thinking that we should add the 40/60 D2O/d-sulfuric
acid mixture to our Solvents table. Has anyone added a similar entry? What
signal values did you use? Or is there another way around this issue?
Thanks!
Wendy
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Received on Tue May 13 2025 - 04:37:52 MST