I've been nerd-sniped! (see
http://xkcd.com/356/).
David's question about the optimal d1 for INADEQUATE using the steady-state (crusher) gradients was relatively easy to solve analytically, but it got me to revisit a problem that I played with 6 years ago when some students were fighting with a stubborn (slow relaxing) quat 13C peak that wasn't showing up in their dilute sample. At that point in time, I simply ran some simulations for a variety of values for T1, at, d1, and flip angle and found that d1=0 and pw=18 degrees seemed to give the best integrated SNR for a fixed length of time (rather surprising to me at the time). Anyhow, I got nerd-sniped into spending my entire weekend trying to prove my previous result for various situations. I'm sure there are journal articles out there that have already tackled this in great detail, but I had a lot of fun playing with this question and I figured that others of you may enjoy this (even if just to laugh at how I spent my weekend...) Attached is a pdf version of my cleaned-up Mathematica notebook; enjoy!
-Scott
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Dr. Scott Burt
Associate Teaching Professor
NMR Facility Manager
Department of Chemistry and Biochemistry
Brigham Young University
C414 BNSN / C008A BNSN
Provo, Utah 84602-5700
Phone: (801) 422-2404
Fax: (801) 422-0153
email: scott_burt_at_byu.edu
Received on Mon Mar 09 2015 - 07:58:10 MST