Date: Tue, 3 Jun 2025 17:20:53 +0000
We have been told that Multiple Solvent Suppression should be possible in
automation and were directed at the LC-NMR manual. The manual does refer to
performing these experiments in automation, but I have not been successful.
Hoping that someone here has been able to get this to work.
We would like to suppress at least 3 peaks. Procedurally, you would first
run a proton, integrate targets peaks and save a .reg file and then run the
solvent suppression. There are two variations - a MULTIPRESAT and a LC1DC
WGPPS parameter sets. Both use noesy shaped pulses. I haven't been successful
with either from within ICON or without. They rely on an au program au_lc1d.
I did get it to work in topspin using an older wet1dc program.
One issue seems to be that while I define one set of frequencies in the .reg
file, it chooses a 3rd peak I didn't select as shown in the image below.
Ken Sharp-Knott
Manager of Analytical Services and the NMR Facility
Department of Chemistry
Virginia Tech
(540)267-6502 (Cell)
(540)231-0885 (Office)
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