Re: [AMMRL] 19F and 1H single channel HOESY (Varian)

From: Spin-Doc <bert.heise_at_spin-doc.net>
Date: Thu, 24 Jul 2025 00:24:14 +0200
Hi, Shawn,

Sorry, I don’t quite understand your last post:
- with a standard H-F{X} OneNMR it is completely impossible to do any H/F experiments. You need either of these probes: ASW, ATB, AutoX-HFX or Omni (HFX-OneNMR - only a very small handful of these were made before Agilent kicked the bucket).

- in a single-highband console like 400MR you don’t need a splitter/combiner to run H/F experiments - this is only required in true dual-highband VNMRS consoles (e.g. hi-lo-hi-lo). 
Single-highband consoles never produce fully overlapping H/F pulses or decoupling - specifically decoupling switches back and forth between e.g. 1H observe and 19F decoupling, so the receiver never experiences any pulses, hencd no filtering required (but also less S/N and more artifacts from chopped acquisition). True dual-highband consoles actually have decoupling on during the entire FID, thus requiring full filtering of the receiver channel from decoupling.

Cheers
Bert

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Am 23.07.2025 um 23:06 schrieb Shawn Wagner via groups.io :

Thanks Bert, David and Baa for the suggestions. I have a 400MR, but it is currently fit with a OneProbe that is not dual tuned for 1H-19F.  I will likely tie the Channel 1 and 2 (on the VNMRS) together with a combiner/splitter. This seems to be the lowest energy solution since it requires just a small hardware change. It's not a core magnet so I don't want to make too many changes. They will be happy if it works since they do a lot of fluorine chemistry.


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Received on Wed Jul 23 2025 - 15:28:48 MST

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