*Job Title:* NMR Spectroscopist
*Job Type:* Full-time
*Work Location:* On-site Cranbury, NJ (with the possibility of assignment to
South Plainfield, NJ).
*Job Description:*
We are seeking an experienced *NMR Spectroscopist* to join our team in the
CDMO industry. The ideal candidate will be responsible for the maintenance
and buildout of our NMR facility, troubleshooting NMR instrumentation, and
performing structural elucidation of small molecule drug substances. This
role also involves identifying and elucidating impurities and degradants, and
effectively communicating NMR data for structural analysis. Strong teamwork
and excellent communication skills are essential.
J-STAR Research, Inc. is a subsidiary of Porton that specializes in providing
contract chemistry services to the biopharmaceutical and biotechnology industry.
Our primary focus is resolving intricate chemistry problems relating to Active
Pharmaceutical Ingredients and Intermediates in the preclinical and clinical
development phases. We are adept in synthetic chemistry and process research
services, which include Process Chemistry, Quality Control, Good Manufacturing
Practice, Quality Assurance, Crystallization Research and Development, Solid
Form and Polymorph Screening, Catalysis Screening and Enabling Technology, High
Potent Compound Handling (HPAPI), Impurity Isolation and Structural Elucidation,
and Preformulation and Formulation Research and Development.
At J-Star, there are 5 NMR systems including one 500 MHz H/C/N Cryoprobe as
well as two 400 MHz Bruker systems with multiple-nuclear and variable temperature
capabilities. We are hiring an NMR Spectroscopist to support project team
decisions and improve the speedy delivery of API for our clients.
*Responsibilities:*
* Oversee the general maintenance and development of the NMR facility.
* Independently troubleshoot and resolve issues with NMR instrumentation.
* Perform structural elucidation of small molecule drug substances, intermediates,
and starting materials.
* Identify and elucidate the structures of related impurities and degradants from
API synthesis, fate and purge, and stress degradation studies.
* Provide clear oral and written explanations of NMR data for structural elucidation.
* Collaborate effectively with a team of chemists.
*Requirements:*
* Ph.D. with 5+ years or MS with 10+ years of post-graduate industrial or
academic experience in small molecule NMR data collection and interpretation.
* Degree in Organic Chemistry, Physical Chemistry, Pharmaceutical Sciences,
Physics, or a related field.
* Experience troubleshooting NMR hardware and software (Bruker and Varian),
including magnets, consoles, conventional and cryoprobes, autosamplers, and
workstations (Windows and Linux).
* Demonstrated ability to creatively apply NMR techniques to pharmaceutical
problems.
* Strong understanding and application of NMR theory for solving chemical
structures and interactions of small molecules.
* Experience using 1D (1H, 13C, 19F, 15N, etc.) and 2D (COSY, ROESY, HSQC,
HMBC, TOCSY, etc.) multinuclear solution-state NMR techniques on high-field
NMR instruments (300-500 MHz) equipped with conventional and cryoprobe technology.
*Experience:*
* NMR Experience: 4 years (Required)
* Pharmaceutical CDMO Industry Experience: 5 years (Preferred)
*Relocation:*
* Must be able to relocate to Cranbury and South Plainfield, NJ before starting
work (Required)
*Work Location:*
* In-person
Please send the resume to
Vivi.cao_at_jstar-research.com
--
Weilin
J-Star Research
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Received on Fri Aug 30 2024 - 09:01:39 MST