Dear AMMRL members,
A group at Stony Brook is working on a Tuberculosis drug discovery
program targeting the fatty acid bio-synthesis type 2 pathway in
Mycobacterium tuberculosis, in this case, using tight binding inhibitors
of InhA (120kD, tetramer), the enoyl ACP reductase in FASII. They have
labeled the protein with a fluorine containing adduct that they hope
might allow them to to probe the mechanisms and chain dynamics they
believe to be involved in the InhA inhibition using 19F NMR observations.
The 19F capable probes that we have present relatively high 19F Teflon
background signals that occlude the 19F resonances from the protein. Do
any of you laboratories posses 19F probes that have low or no 19F
background signals or do you know of groups that do? Beyond the
possession or knowledge, is there any interest in sharing access to the
technology once identified? If a list develops I will post it to the
group with the permissions of those who wish to be exposed in that way.
Thank you.
--
Francis Picart
NMR Coordinator
SUNY Stony Brook
Department of Chemistry
100 John S. Toll Drive, Room 507
Stony Brook, New York 11794-3400
francis_at_anmfpc5.chem.sunysb.edu
Francis.Picart_at_stonybrook.edu
(631)632-7991 Office
(631)632-7960 Fax
Received on Wed Sep 15 2010 - 16:23:06 MST