Dear Denis, Mike and all
Thanks for your answer :
I usually use s/n >=3 for LOD and s/n >= 10 for LOQ.
This works fine in the case of a singulet peak as in HPLC.
In the case of a quadruplet for example with, for example, intensities 1 4 4
1, if the highest peak of the quadruplet (4) is above the LOQ, the smallest
(1) are even below the LOD.
I was wondering if somebody has already published something or thought about
the LOQ of multiplets :
To me, two posibilities could ne envisaged :
- a general and big value for the s/n ratio for LOQ (i.e. 50) then most of
the cases would be covered (LOD of 3 for the highest peak is still ol in the
case of multiplets)
- or the smallest peak of the multiplet above 10 (may be difficult to
estimate for complex multiplets...)
We have to consider integration instead of intensities, and S/N vs
integration is not linear...
Any other ideas ?
Hope this helps
Francois
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Dr. Francois CROIZET - Riom Laboratoires CERM
Chemistry Dept. - Structure Elucidation Group
ZI de la Varenne, 22 Rue H. Goudier, BP 140 -
63203 RIOM Cedex - FRANCE -
Phone: (33) 473 33 74 08 - Fax: (33) 473 33 49 97
E-mail: f.croizet_at_organon.rim.akzonobel.nl
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Received on Wed Oct 04 2000 - 08:56:39 MST