Hi David,
you can also try turning off the lock during data acquisition. The easiest
way to do this is to use the pulsprogram zgig2h This is a sequence that is
designed to do a 1D with deuterium decoupling during acquisition. It will
lock during the relaxation delay and switch to 2H pulsing during collection
of the FID.
This effectively disconnects the lock from the probe. You can set observe to
6Li and the decoupling nucleus to 2H and set the decoupler power to 0W or
1000 db
Let me know if this helps.
Clemens
On 6/8/2026 1:41 PM, David Halat via groups.io wrote:
Hi all,
We are trying to run 6Li solution NMR on a Bruker 400 MHz system and appear
to be getting, perhaps unsurprisingly, substantial 2H lock-related noise
in our 6Li NMR spectra. The screenshot here shows experiments that are
nominally identical except that the red spectrum was run with lock on, and
gave multiple ADC overflow warnings. Running without 2H lock seems to
significantly help the noise problem (blue spectrum). However, we would
like to ultimately run some 6Li experiments with 2H locking to avoid
drift in longer experiments to improve SNR.
I thought that preamp filtering might help here. I see that there is a preamp
filter that Bruker provides, seen below - does anyone know how to get a hold
of a Bruker 400 MHz 6Li-pass / 2H-stop filter, or who the right contact would
be, assuming these parts are still manufactured? Or any other advice that
might help here? Thanks!
The specific part I found is Z42408, listed in Bruker manual Z31430_09
https://2210pc.chem.uic.edu/nmr/downloads/bruker/en-US/pdf/z31430_9.pdf
as Z42408 FILTER 400 6LI-PASS / 2H-STOP
Best,
David
--
==========================
==========================
====================
Clemens Anklin Ph.D. Vice President
Bruker BioSpin NMR Applications & Training
15 Fortune Drive NEW Phone: 978-313-5NMR(5667)
Billerica MA 01821 bluesky: _at_canklin.bsky.social
web: http://www.bruker.com
e-mail: clemens.anklin_at_bruker.com
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Received on Mon Jun 08 2026 - 12:17:31 MST