AMMRL: H1-N15 CIGAR-MBC(ACCORD,IMPEACH-MBC)
>
> Dear AMMRLers:
>
> This question is for H1-N15 CIGAR-MBC. I used the cigar-mbc pulse sequence
> for Varian Innova 300mHz and two channel 5mm ID probe and got the spectra
> for formamide (45% natural abundance formamide and 55% DMSO-d6) and
> N,N-dimethylacetamide (50%/50% in DMSO). I can get the contours from the
> 2JHN in formamide and 2JHN, 3JHN in NNDAA. But when I switched to
> benzylamine, I was not able to get the contours from 2JHN (CH2-NH2).
> Although the H1 channel (F2) gave two proton peaks, the 2D spectra seemed
> messed up. Instead of two contours from 2JHN and 4JHN, there are two dotted
> lines along the N15 channel. The H chemical shift for the two lines are
> right though. Since due to the fast exchange of amine proton, one-bond
> HS(M)QC did not work for amines.My questions will be:
>
> 1. from your experience, does the CIGAR work for amine?
>
> 2. how to make it work? I have been adjusting the N15 spectrum window and
> optimizing the pwx and other parameters, but no luck yet.
> 3. does the CIGAR work for some N contained heteronuclear ring structure,
> such as imidazoline, imidazolinium?
>
> 4. How about ACCORD or IMPEACH-MBC? Where to get those pulse sequence?
>
> Thanks,
>
> Xin Jia, PhD
>
> Research Scientist
>
> Innovation Institute
>
> Georgia-Pacific Corporation
>
> Neenah,WI
>
>
Received on Tue Jan 23 2007 - 13:47:27 MST
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