Dear colleagues,
We'd like to ask for your expertise on a problem we've been experiencing for
several weeks with our Bruker NEO 600 spectrometer.
We are used to performing DOSY experiments on a regular basis, but we are no
longer able to do so. When we vary the intensity of the gradient linearly,
we observe random intensity changes that are clearly not related to diffusion.
Signals can drop sharply and then rise again. We have verified that the problem
is not related to convection. In particular, we see the same effects with
anti-convection sequences. We were unable to identify any gradient values that
were more problematic than others. We carried out a number of tests (non-linear
ramping, changing the order of the different gradients, play with gradients shape,
use of different topspin version ...) but no convincing results. In a way that
seems totally random, the signal decreases sharply for certain slices of the DOSY.
On the other hand, when we use the 1D versions, the behavior looks normal and if
we run a succession of spectra, we don't see this random behavior.
Have any users already encountered this problem or have any idea where it might
be coming from?
Thank you for your help,
Yannick
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Received on Fri Dec 08 2023 - 08:30:02 MST