I am seeking assistance with the following problem.
I have compounds that are soluble in DMSO and chloroform. They could have
several possible optical isomers and I am trying determine which
configuration is correct. Could you recommend NMR articles, NMR
experiments, chemical modification and chiral NMR chemicals that would help
determine the absolute configuration of compounds.
The question involves orientation of H and an OH groups around chiral
carbons. There are no ionizable groups except the OH possible exchanging H.
My prior experience was using 1D NOE of a well characterized and rigid
molecule, this new molecule is more sugar-like.
Thank you for any suggestions for determining absolute configurations.
Rob Kleps
Robert A. Kleps, Ph.D. kleps_at_uic.edu
NMR Laboratory 312-996-8550 or
Research Resources Center 312-996-7600
835 S. Wolcott Avenue FAX 312-996-0539
Chicago, IL. 60612
Received on Tue Dec 18 2001 - 10:24:49 MST