Colleagues,
I've been looking for a reference list of good quantitative standards
(compounds to add to NMR samples to calibrate integrals to
concentration). If any of you could let me know what standards you've
used or considered for quantitative work, I'll post a summary. If anyone
can provide references to any published lists, I will burn prayer offerings
on the altar of our lab gods for the success of your work and career. And
create opportunities to cite your papers.
A good standard would have a single sharp line in an unobtrusive region of
the spectrum (TMS at 0 ppm, methylene chloride at 5.1 ppm).
An ideal standard would also have
- a reasonably short T1 (unlike TMS and TMSP tend to be 5 sec or
longer).
- volatile enough to be removed from the sample after NMR (TMSP can
be pulled off nicely).
- not too volatile to add to the sample quantitatively ( TMS is a
bit ethereal).
I've seen pyrazine mentioned in the archives. There was a recent paper on
BTMSB (bis trimethylsilyl benzene) for DMSO.
-- Roger
-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+-+=+
-+=+
Roger
Kautz
Director, NMR Facility
taff Scientist,
Ph.D.
tel 617 373-8211
oom 341 Mugar Life Science
Bldg.
fax 2855
Barnett Institute of Chemical and Biological Analysis
Northeastern University, 360 Huntington Ave, Boston MA 02115
Received on Fri Aug 02 2002 - 16:01:33 MST