Dear Spinlanders,
I'd like to share an NMR-centric job posting:
Analytical and Structural Chemistry - Identification and characterisation of protein/peptides modifications in formulated media
Location- Cambridge UK
Salary: Competitive
If you're inspired to work for a world premier biotechnology company delivering life-changing products- join us.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.
We lead our industry in our development of a strong and varied pipeline. This means our people are here to win, we give you a breadth of opportunities to be curious and do cutting edge, unique work that has a big impact on science and medicine.
The Role
This is an exciting opportunity to work within our Global Analytical Sciences Group based at the Medimmune Cambridge facility. You will be joining the team involved in the development of biological and synthetic peptide drug candidates to support early clinical trials, product stability assessment and technology transfer. With an exciting research pipeline, this is a great time to develop your career with MedImmune.
We are seeking a scientist with expertise in analytical and structural chemistry of peptides and proteins to support understanding of degradation pathways of peptide and protein in formulations. Your main responsibilities will be to lead activities for the characterisation of product-related impurities observed on protein manufacture or generated on product storage. In this role you will identify and characterise, using NMR spectroscopy and other analytical techniques, structural alterations on the primary structure and side-chain modifications of peptides/small protein fragments caused by side reactions, oligomerisation processes and/or post-translational modifications.
As the lead scientist you will provide extensive theoretical understanding or chemical degradation/modification pathways and hands on expertise in developing and implementing NMR spectroscopy methods for structural characterisation and quantitation of these impurities. Data will be used to support regulatory filings.
Essential Requirements
* NMR spectroscopy background with experience in characterisation of proteins, peptides or organic molecules
* Proven track record of analytical and structural sciences applied to peptide chemistry gained within an academic or industry environment.
* Hands on experience on analytical techniques used in organic/peptide chemistry, and proteins characterisation, eg MS spectrometry and chromatography.
* Educated to BSc/MSc/PhD in a relevant scientific discipline.
Desirable Requirements
* Experience with peptide drug development
* PhD in a related area.
Next Steps - Apply today!
To be considered for this exciting opportunity, please complete the full application on our website:
https://careers.astrazeneca.com/medimmune
Job reference: R-044265
https://astrazeneca.wd3.myworkdayjobs.com/Careers/job/UK---Cambridge/Analytical-Chemist--Scientist-I--1-year-FTC_R-044265-2
If you know someone who would be a great fit, please share this posting with them.
The closing date for this application is 25-Apr-2019
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Thanks,
Amber
Amber Y.S. Balazs, PhD
Analytical and Structural Chemistry
NMR Specialist
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Oncology R&D Boston, AstraZeneca
amber.balazs_at_astrazeneca.com<mailto:amber.balazs_at_astrazeneca.com>
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Received on Tue Apr 16 2019 - 22:06:18 MST